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Species Variability in Cardiovascular Research: The Example of Adrenocorticotrophin-Induced Hypertension

Whitworth, Judith; Zhang, Yi; Mangos, George; Kelly, John J


1. Lawrie Beilin has contributed greatly to international hypertension research through both animal and human studies. 2. Animals are used in biomedical research to gain insights that can be extrapolated ultimately to humans. 3. A simple experimental manipulation, adrenocorticotrophin (ACTH) administration, has a range of different cardiovascular effects in different species. 4. Caution should be exercised in extrapolating data from animals to humans.

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Clinical and Experimental Pharmacology and Physiology
DOI: 10.1111/j.1440-1681.2006.04460.x


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