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Developmental kinetics, turnover and stimulatory capacity of thymic epithelial cells

Gray, Daniel H D; Seach, Natalie; Ueno, Tomoo; Milton, Morag; Liston, Adrian; Lew, Andrew M; Goodnow, Christopher; Boyd, Richard L


Despite the importance of thymic stromal cells to T-cell development, relatively little is known about their biology. Here, we use single-cell analysis of stromal cells to analyze extensive changes in the number and composition of thymic stroma throughout life, revealing a surprisingly dynamic population. Phenotypic progression of thymic epithelial subsets was assessed at high resolution in young mice to provide a developmental framework. The cellular and molecular requirements of adult...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Blood
DOI: 10.1182/blood-2006-02-004531


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