Investigating the self-assembly and molecular chaperone ability of casein proteins and polyproline
Caseins are a group of intrinsically disordered proteins (IDPs) present in the milk of all mammals. A property common to many IDPs is their propensity to assemble into amyloid fibrils, which are associated with many age-related diseases. Based on the stability of their predicted 'steric zipper' structures, which form the backbone of amyloid fibrils, caseins from all species contain amyloidogenic sequences. Such sequences in caseins are mainly located in their proline/glutamine (P,Q)-rich...[Show more]
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