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Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

El-Assaad, Wissal; Buteau, Jean; Peyot, Marie-Line; Nolan, Christopher; Roduit, Raphael; Hardy, Serge; Joly, Erik; Dbaibo, Ghassan; Rosenberg, Lawrence; Prentki, Marc


We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty acids (FFAs) together with hyperglycemia are synergistic in causing islet β-cell damage because high glucose inhibits fat oxidation and consequently lipid detoxification. Th

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Endocrinology
DOI: 10.1210/en.2003-0410


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