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Conductance properties of the inwardly rectifying channel, Kir3.2: Molecular and 2 Brownian dynamics study

Hilder, Tamsyn; Chung, Shin-Ho


Using the recently unveiled crystal structure, and molecular and Brownian dynamics simulations, we elucidate several conductance properties of the inwardly rectifying potassium channel, Kir3.2, which is implicated in cardiac and neurological disorders. We show that the pore is closed by a hydrophobic gating mechanism similar to that observed in Kv1.2. Once open, potassium ions move into, but not out of, the cell. The asymmetrical current-voltage relationship arises from the lack of negatively...[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Biochimica et Biophysica Acta: Biomembranes
DOI: 10.1016/j.bbamem.2012.09.022


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