Mechanistic Studies of Cholesterol Lipotoxicity Pertinent to NASH
Non-alcoholic fatty liver disease (NAFLD) affects ~30% of the world population with similar or higher prevalence in Australia. The pathology of NAFLD ranges from benign simple steatosis (SS) to non-alcoholic steatohepatitis (NASH), with fibrosis that can progress to cirrhosis. Understanding the pathogenesis of NASH remains a challenge. In both humans and mice, obesity, diabetes and metabolic syndrome are associated with NAFLD, but free cholesterol (FC)...[Show more]
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