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CD8+ T cell-mediated immune responses in West Nile virus (Sarafend strain) encephalitis are independent of gamma interferon

Wang, Yang; Lobigs, Mario; Lee, Eva; Koskinen, Aulikki; Mullbacher, Arno


The flavivirus West Nile virus (WNV) can cause fatal encephalitis in humans and mice. It has recently been demonstrated, in an experimental model using WNV strain Sarafend and C57BL/6 mice, that both virus- and immune-mediated pathology is involved in WNV encephalitis, with CD8+ T cells being the dominant subpopulation of lymphocyte infiltrates in the brain. Here, the role of activated WNV-immune CD8+ T cells in mouse WNV encephalitis was investigated further. Passive transfer of WNV-immune...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Journal of General Virology
DOI: 10.1099/vir.0.81306-0


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