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Dihydropyridine-insensitive calcium currents contribute to function of small cerebral arteries

Kuo, Ivana; Ellis, Anthie; Seymour, Victoria; Sandow, Shaun, L; Hill, Caryl


Although dihydropyridines are widely used for the treatment of vasospasm, their effectiveness is questionable, suggesting that other voltage-dependent calcium channels (VDCCs) contribute to control of cerebrovascular tone. This study therefore investigated the role of dihydropyridine-insensitive VDCCs in cerebrovascular function. Using quantitative PCR and immunohistochemistry, we found mRNA and protein for L-type (CaV 1.2) and T-type (Ca V 3.1 and CaV 3.2) channels in adult rat basilar and...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Journal of Cerebral Blood Flow and Metabolism
DOI: 10.1038/jcbfm.2010.11


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