Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk
Blackburn, Anneke; Hill, Linda Z.; Roberts, Amy L.; Wang, Jun; Aud, Dee; Jung, Jimmy; Nikolcheva, Tania; Allard, John; Peltz, Gary; Otis, Christopher; Cao, Qing; Ricketts, Reva St. J.; Naber, Stephen P; Mollenhauer, Jan; Poustka, A; Malamud, Daniel; Jerry, Joseph
Low-penetrance breast cancer susceptibility alleles seem to play a significant role in breast cancer risk but are difficult to identify in human cohorts. A genetic screen of 176 N2 backcross progeny of two Trp53+/- strains, BALB/c and C57BL/6, which differ in their susceptibility to mammary tumors, identified a modifier of mammary tumor susceptibility in an ∼25-Mb interval on mouse chromosome 7 (designated SuprMam1). Relative to heterozygotes, homozygosity for BALB/c alleles of SuprMam1...[Show more]
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|Source:||American Journal of Pathology|
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