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Lipid-related genetic polymorphisms significantly modulate the association between lipids and disability progression in multiple sclerosis

Zhang, Yan; Zhou, Yuan; van der Mei, Ingrid A. F.; Simpson, Steve; Ponsonby, Anne-Louise; Lucas, Robyn; Tettey, Prudence; Charlesworth, Jac C.; Kostner, Karam; Taylor, B. V.


Objective To investigate whether lipid-related or body mass index (BMI)–related common genetic polymorphisms modulate the associations between serum lipid levels, BMI and disability progression in multiple sclerosis (MS). Methods The association between disability progression (annualised Expanded Disability Status Scale (EDSS) change over 5 years, ΔEDSS) and lipid-related or BMI-related genetic polymorphisms was evaluated in a longitudinal cohort (n=184), diagnosed with MS. We constructed a...[Show more]

CollectionsANU Research Publications
Date published: 2019-05-16
Type: Journal article
Source: Journal of Neurology, Neurosurgery & Psychiatry
DOI: 10.1136/jnnp-2018-319870
Access Rights: Open Access


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