Hu, Lexian; Zhang, Yi; Lim, Pek (Chloe); Miao, Yuchun; Tan, Chrismin; McKenzie, Katja; Schyvens, Chris; Whitworth, Judith
Background: Dexamethasone (Dex)-hypertension in rats is associated with increased oxidative stress. We investigated effects of the NAD(P)H oxidase inhibitor apocynin and the nitric oxide (NO) precursor l-arginine on Dex-hypertension to determine the relative roles of NAD(P)H oxidase and uncoupling in the reactive oxygen species (ROS) generation and hypertension. Methods: Male Sprague-Dawley rats (n = 10/group) received Dex (20 μg/kg/day subcutaneously) or saline (vehicle) for 14 days. In a...[Show more]
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