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Apocynin but Not-L-Arginine Prevents and Reverses Dexamethasone-Induced Hypertension in the Rat

Hu, Lexian; Zhang, Yi; Lim, Pek (Chloe); Miao, Yuchun; Tan, Chrismin; McKenzie, Katja; Schyvens, Chris; Whitworth, Judith


Background: Dexamethasone (Dex)-hypertension in rats is associated with increased oxidative stress. We investigated effects of the NAD(P)H oxidase inhibitor apocynin and the nitric oxide (NO) precursor l-arginine on Dex-hypertension to determine the relative roles of NAD(P)H oxidase and uncoupling in the reactive oxygen species (ROS) generation and hypertension. Methods: Male Sprague-Dawley rats (n = 10/group) received Dex (20 μg/kg/day subcutaneously) or saline (vehicle) for 14 days. In a...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: American Journal of Hypertension
DOI: 10.1016/j.amjhyper.2005.09.023


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