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Enhanced antiviral antibody secretion and attenuated immunopathology during influenza virus infection in nitric oxide synthase-2-deficient mice

Jayasekera, Jerome P.; Garcia De Vinuesa, Maria Carola; Karupiah, Gunasegaran; King, Nicholas J.C.


NOS2 gene-deficient (NOS2-/-) mice are less susceptible than wild-type (NOS2+/+) mice to infection with Influenza A virus. Virus titres in the lungs of influenza-infected NOS2-/- mice are significantly lower than those in NOS2+/+ mice, with enhanced viral clearance in NOS2-/- mice dependent on gamma interferon (IFN-γ). The current study was undertaken to ascertain the role of specific components of the immune response in promoting virus clearance in influenza-infected NOS2-/- mice. Levels of T...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Journal of General Virology
DOI: 10.1099/vir.0.82131-0


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