Modulation of pancreatic islets-stress axis by hypothalamic releasing hormones and 11 beta-hydroxysteroid dehydrogenase
Schmid, Janine; Ludwig, Barbara; Schally, Andrew V.; Steffen, Anja; Ziegler , Christian G; Block, Norman L; Koutmani, Yassemi; Brendel, Mathias D; Karalis, Katia P; Simeonovic, Charmaine; Licinio, Julio; Ehrhart-Bornstein, Monika; Bornstein, SR
Corticotropin-releasing hormone (CRH) and growth hormone-releasing hormone (GHRH), primarily characterized as neuroregulators of the hypothalamic- pituitary-adrenal axis, directly influence tissue-specific receptor-Systems for CRH and GHRH in the endocrine pancreas. Here, we demonstrate the expression of mRNA for CRH and CRH-receptor type 1 (CRHR1) and of protein for CRHR1 in rat and human pancreatic islets and rat insulinoma cells. Activation of CRHR1 and GHRH-receptor significantly increased...[Show more]
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