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Use of quantitative PCR to assess the efficacy of albendazole against Necator americanus and Ascaris spp. in Manufahi District, Timor-Leste

Vaz Nery, Susana; Qi, Jessica; Llewellyn, Stacey; Clarke, Naomi; Traub, Rebecca; Gray, Darren; Vallely, Andrew; Williams, Gail; Andrews, Ross M.; McCarthy, James; Clements, Archie

Description

Soil-transmitted helminths (STHs) including Ascaris lumbricoides, Necator americanus, Ancylostoma spp. and Trichuris trichiura are cause of significant global morbidity. To mitigate their disease burden, at-risk groups in endemic regions receive periodic mass drug administration using anthelmintics, most commonly albendazole and mebendazole. Assessing the efficacy of anthelmintic drugs is important for confirming that these regimens are working effectively and that drug resistance has not...[Show more]

dc.contributor.authorVaz Nery, Susana
dc.contributor.authorQi, Jessica
dc.contributor.authorLlewellyn, Stacey
dc.contributor.authorClarke, Naomi
dc.contributor.authorTraub, Rebecca
dc.contributor.authorGray, Darren
dc.contributor.authorVallely, Andrew
dc.contributor.authorWilliams, Gail
dc.contributor.authorAndrews, Ross M.
dc.contributor.authorMcCarthy, James
dc.contributor.authorClements, Archie
dc.date.accessioned2019-10-15T01:22:42Z
dc.date.available2019-10-15T01:22:42Z
dc.identifier.issn1756-3305
dc.identifier.urihttp://hdl.handle.net/1885/176592
dc.description.abstractSoil-transmitted helminths (STHs) including Ascaris lumbricoides, Necator americanus, Ancylostoma spp. and Trichuris trichiura are cause of significant global morbidity. To mitigate their disease burden, at-risk groups in endemic regions receive periodic mass drug administration using anthelmintics, most commonly albendazole and mebendazole. Assessing the efficacy of anthelmintic drugs is important for confirming that these regimens are working effectively and that drug resistance has not emerged. In this study we aimed to characterise the therapeutic efficacy of albendazole against Ascaris spp. and N. americanus in Timor-Leste, using a quantitative polymerase chain reaction (qPCR) method for parasite detection and quantification.
dc.description.sponsorshipNEC is supported by an Australian Government Research Training Program Scholarship, ACAC and AJV are supported by a National Health and Medical Research Council (NHMRC) Senior Research Fellowship, JSM is an Australian NHMRC Practitioner Fellow and DJG is an Australian NHMRC Career Development Fellow. This work is funded by an NHMRC Partnership project in collaboration with WaterAid Australia.
dc.format.extent7 pages
dc.format.mimetypeapplication/pdf
dc.language.isoen_AU
dc.publisherBioMed Central
dc.rights© The Author(s). 2018
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceParasites and Vectors
dc.subjectAlbendazole
dc.subjectEfficacy
dc.subjectNecator americanus
dc.subjectAscaris lumbricoides
dc.subjectHookworm
dc.subjectSoil-transmitted helminths
dc.subjectAnthelminthic drug efficacy
dc.titleUse of quantitative PCR to assess the efficacy of albendazole against Necator americanus and Ascaris spp. in Manufahi District, Timor-Leste
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume11
dcterms.dateAccepted2018-04-09
dc.date.issued2018-06-28
local.identifier.absfor111706 - Epidemiology
local.identifier.ariespublicationa383154xPUB10207
local.publisher.urlhttps://www.biomedcentral.com/
local.type.statusPublished Version
local.contributor.affiliationVaz Nery, Susana, College of Health and Medicine, The Australian National University
local.contributor.affiliationQi, Jessica, College of Health and Medicine, The Australian National University
local.contributor.affiliationLlewellyn, Stacey, QIMR Berghofer Medical Research Institute
local.contributor.affiliationClarke, Naomi, College of Health and Medicine, The Australian National University
local.contributor.affiliationTraub, Rebecca, University of Melbourne
local.contributor.affiliationGray, Darren, College of Health and Medicine, The Australian National University
local.contributor.affiliationVallely, Andrew, University of New South Wales
local.contributor.affiliationWilliams, Gail, University of Queensland
local.contributor.affiliationAndrews, Ross M., Charles Darwin University
local.contributor.affiliationMcCarthy, James, QIMR Berghofer Medical Research Institute
local.contributor.affiliationClements, Archie, College of Health and Medicine, The Australian National University
local.bibliographicCitation.issue373
local.identifier.doi10.1186/s13071-018-2838-0
local.identifier.absseo920203 - Diagnostic Methods
dc.date.updated2019-05-05T08:53:22Z
local.identifier.scopusID2-s2.0-85049196364
dcterms.accessRightsOpen Access
dc.rights.licenseThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
CollectionsANU Research Publications

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