Shield, Alison; Thomae, Bianca; Eckloff, Bruce; Wieben, Eric; Weinshilboum, Richard
Catechol O-methyltransferase (COMT) plays an Important role in the metabolism of catecholamlnes, catecholestrogens and catechol drugs. A common COMT G472A genetic polymorphism (Val108/158Met) that was identified previously is associated with decreased levels of enzyme activity and has been implicated as a possible risk factor for neuropsychiatric disease. We set out to 'resequence' the human COMT gene using DNA samples from 60 African-American and 60 Caucasian-American subjects. A total of 23...[Show more]
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