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Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system

Belov, Katherine; Sanderson, Claire; Deakin, Janine; Wong, Emily; Assange, Daniel; McColl, Kaighin A; Gout, Alex; de Bono, Bernard; Barrow, Alexander D; Speed, Terence P; Trowsdale, John; Papenfuss, Anthony T

Description

The availability of the first marsupial genome sequence has allowed us to characterize the immunome of the gray short-tailed opossum (Monodelphis domestica). Here we report the identification of key immune genes, including the highly divergent chemokines, defensins, cathelicidins, and Natural Killer cell receptors. It appears that the increase in complexity of the mammalian immune system occurred prior to the divergence of the marsupial and eutherian lineages ∼180 million years ago. Genomes of...[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
URI: http://hdl.handle.net/1885/17615
Source: Genome Research
DOI: 10.1101/gr.6121807

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