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Leptin replacement therapy for the treatment of non-HAART associated lipodystrophy syndromes: a meta-analysis into the effects of leptin on metabolic and hepatic endpoints

Rodriguez, Alexander; Neeman, Teresa; Giles, Aaron; Mastronardi, Claudio; Da Paz Filho, Gilberto


The clinical manifestations of lipodystrophy syndromes (LS) are hypoleptinemia, hyperglycemia, insulin resistance, dyslipidemia and hepatic steatosis. Leptin replacement therapy (LRT) is effective at improving these pathologies. Currently, there are no data compiling the evidence from the literature, and demonstrating the effect of LRT in LS patients. A systematic review of the MEDLINE and Cochrane Library databases was conducted to identify studies assessing the effect of LRT on metabolic and...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Arquivos Brasileiros de Endocrinologia e Metabologia
DOI: 10.1590/0004-2730000003174


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