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The structure of the C-terminal helical bundle in glutathione transferase M2-2 determines its ability to inhibit the cardiac ryanodine receptor

Hewawasam, Ruwani; Liu, Dan; Casarotto, Marco; Dulhunty, Angela; Board, Philip

Description

Ca2+ release from the sarcoplasmic reticulum through cardiac ryanodine receptors (RyR2) is essential for heart function and is inhibited by the carboxy terminal domain of glutathione transferase M2-2 (GSTM2-C) and derivative fragments containing helix 6.

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
URI: http://hdl.handle.net/1885/17374
Source: Biochemical Pharmacology
DOI: 10.1016/j.bcp.2010.04.019

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