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RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest

Hannan, Katherine; Kennedy, Brian K.; Cavanaugh, Alice H.; Hannan, Ross; Hirschler-Laszkiewicz, Iwona; Jefferson, L. S.; Rothblum, Lawrence I.


When 3T6 cells are confluent, they withdraw from the cell cycle. Concomitant with cell cycle arrest a significant reduction in RNA polymerase I transcription (80% decrease at 100% confluence) is observed. In the present study, we examined mechanism(s) through which transcription of the ribosomal genes is coupled to cell cycle arrest induced by cell density. Interestingly with an increase in cell density (from 3–43% confluence), a significant accumulation in the cellular content of...[Show more]

CollectionsANU Research Publications
Date published: 2000
Type: Journal article
Source: Oncogene
DOI: 10.1038/sj.onc.1203690


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