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Platypus Induced Pluripotent Stem Cells: The Unique Pluripotency Signature of a Monotreme

Whitworth, Deanne J.; Limnios, Ioannis; Gauthier, Marie-Emilie; Weeratunga, Prasanna; Ovchinnikov, Dmitry A.; Baillie, Gregory; Grimmond, Sean M.; Graves, Jennifer; Wolvetang, Ernst

Description

The platypus (Ornithorhynchus anatinus) is an egg-laying monotreme mammal whose ancestors diverged ∼166 million years ago from the evolutionary pathway that eventually gave rise to both marsupial and eutherian mammals. Consequently, its genome is an extraordinary amalgam of both ancestral reptilian and derived mammalian features. To gain insight into the evolution of mammalian pluripotency, we have generated induced pluripotent stem cells from the platypus (piPSCs). Deep sequencing of the piPSC...[Show more]

CollectionsANU Research Publications
Date published: 2019-02-01
Type: Journal article
URI: http://hdl.handle.net/1885/173108
Source: Stem Cells and Development
DOI: 10.1089/scd.2018.0179

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