Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors
Immunological memory is characterized by heightened immunoglobulin (Ig) G antibody production caused in part by enhanced plasma cell formation conferred by conserved transmembrane and cytoplasmic segments in isotype-switched IgG B cell receptors. We tested the hypothesis that the IgG tail enhances intracellular B cell antigen receptor (BCR) signaling responses to antigen by analyzing B cells from Ig transgenic mice with IgM receptors or chimeric IgMG receptors containing the IgG tail segment....[Show more]
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|Source:||Journal of Experimental Medicine|
|01_Horikawa_Enhancement_and_suppression_of_2007.pdf||3.39 MB||Adobe PDF||Request a copy|
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