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Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors

Horikawa, Keisuke; Martin, Stephen; Pogue, Sarah; Silver, Karlee; Peng, Kaimen; Takatsu, Kiyoshi; Goodnow, Christopher


Immunological memory is characterized by heightened immunoglobulin (Ig) G antibody production caused in part by enhanced plasma cell formation conferred by conserved transmembrane and cytoplasmic segments in isotype-switched IgG B cell receptors. We tested the hypothesis that the IgG tail enhances intracellular B cell antigen receptor (BCR) signaling responses to antigen by analyzing B cells from Ig transgenic mice with IgM receptors or chimeric IgMG receptors containing the IgG tail segment....[Show more]

CollectionsANU Research Publications
Date published: 2007
Type: Journal article
Source: Journal of Experimental Medicine
DOI: 10.1084/jem.20061923


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