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Dissociation between epitope hierarchy and immunoprevalence in CD8 responses to vaccinia virus Western Reserve

Oseroff, Carla; Peters, Bjoern; Pasquetto, Valerie; Moutaftsi, Magdalini; Sidney, John; Panchanathan, Vijay; Tscharke, David; Maillere, Bernard; Grey, Howard; Sette, Alessandro


Understanding immunity to vaccinia virus (VACV) is important for the development of safer vaccines for smallpox- and poxvirus-vectored recombinant vaccines. VACV is also emerging as an outstanding model for studying CD8+ T cell immu-nodominance because of the large number of CD8+ T cell epitopes known for this virus in both mice and humans. In this study, we characterize the CD8+ T cell response in vaccinated BALB/c mice by a genome-wide mapping approach. Responses to each of 54 newly...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of Immunology


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