Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI
montague, samantha; Delierneux, Céline; Lecut, Christelle; Layios, Nathalie; Lee, Christine; Dinsdale, Robert J.; Poulter, Natalie; Andrews, R.K.; Hampson, Peter; Wearn, Christopher M.; Maes, Nathalie; Bishop, Jonathan; Gardiner, Elizabeth
Soluble glycoprotein VI (sGPVI) is shed from the platelet surface and is a marker of platelet activation in thrombotic conditions. We assessed sGPVI levels together with patient and clinical parameters in acute and chronic inflammatory conditions, including patients with thermal injury and inflammatory bowel disease and patients admitted to the intensive care unit (ICU) for elective cardiac surgery, trauma, acute brain injury, or prolonged ventilation. Plasma sGPVI was measured by enzyme-linked...[Show more]
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