Delineating the role of IL-21 in different phases of CD8+ T cell immune response
Anti-tumour immune responses are largely carried out by cytotoxic immune cells including CD8+ T cells and natural killer (NK) cells. Studies have shown that interleukin-21 (IL-21) can work synergistically with IL-7 or IL-15 to induce proliferation of both memory and naive CD8+ T cells. On its own, IL-21 enhances the production of interferon-gamma (IFNg), perforin and granzyme B (Gzm B), which are the key effector molecules sustaining the cytotoxic activity of CD8+ T cells, via the induction of...[Show more]
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