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Loss of heterozygosity occurs via mitotic recombination in Trp53+/- mice and associates with mammary tumor susceptibility of the BALB/c strain

Blackburn, Anneke; McLary, S Christine; Naaem, Rizwan

Description

Loss of heterozygosity (LOH) occurs commonly in cancers causing disruption of tumor suppressor genes and promoting tumor progression. BALB/c-Trp53 +/- mice are a model of Li-Fraumeni syndrome, exhibiting a high frequency of mammary tumors and other tumor

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/17191
Source: Cancer Research
DOI: 10.1158/0008-5472.CAN-03-3435

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