EXCITATION-CONTRACTION COUPLING FROM THE 1950s INTO THE NEW MILLENNIUM
1. Excitation-contraction coupling is broadly defined as the process linking the action potential to contraction in striated muscle or, more narrowly, as the process coupling surface membrane depolarization to Ca 2+ release from the sarcoplasmic reticulum. 2. We now know that excitation-contraction coupling depends on a macromolecular protein complex or 'calcium release unit'. The complex extends the extracellular space within the transverse tubule invaginations of the surface membrane, across...[Show more]
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|Source:||Clinical and Experimental Pharmacology and Physiology|
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