Tay, Szun; Wong, Yik Chun; Roediger, Ben; Sierro, Frederic; Lu, Bo; McDonald, David M.; McGuffog, Claire M; Meyer, Nicholas J.; Alexander, Ian E.; Parish, Ian; Heath, William R
Naive T cell activation is normally restricted to the lymphoid organs, in part because of their limited ability to migrate into the parenchyma of peripheral tissues. The liver vasculature is unique, however, and circulating leukocytes within the hepatic sinusoids have direct access to liver-resident cells, which include an abundant population of Kupffer cells. It is well accepted that recognition of cognate Ag within the liver leads to naive CD8+T cell activation in situ, but it is unclear...[Show more]
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