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Treatment of Erythrocytes with the 2-Cys Peroxiredoxin Inhibitor, Conoidin A, Prevents the Growth of Plasmodium falciparum and Enhances Parasite Sensitivity to Chloroquine

Brizuela, Mariana; Huang, Hong Ming; Smith, Clare; Burgio, Gaetan; Foote, Simon J.; McMorran, Brendan J.


The human erythrocyte contains an abundance of the thiol-dependant peroxidase Peroxiredoxin-2 (Prx2), which protects the cell from the pro-oxidant environment it encounters during its 120 days of life in the blood stream. In malarial infections, the Plasmodium parasite invades red cells and imports Prx2 during intraerythrocytic development, presumably to supplement in its own degradation of peroxides generated during cell metabolism, especially hemoglobin (Hb) digestion. Here we demonstrate...[Show more]

CollectionsANU Research Publications
Date published: 2014-04-03
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0092411


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