Brizuela, Mariana; Huang, Hong Ming; Smith, Clare; Burgio, Gaetan; Foote, Simon J.; McMorran, Brendan J.
The human erythrocyte contains an abundance of the thiol-dependant peroxidase Peroxiredoxin-2 (Prx2), which protects the cell from the pro-oxidant environment it encounters during its 120 days of life in the blood stream. In malarial infections, the Plasmodium parasite invades red cells and imports Prx2 during intraerythrocytic development, presumably to supplement in its own degradation of peroxides generated during cell metabolism, especially hemoglobin (Hb) digestion. Here we demonstrate...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.