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A Structural Basis for Cellular Uptake of GST-Fold Proteins

Morris, Melanie J.; Liu, Dan; Weaver, Llara M.; Board, Philip G.; Casarotto, Marco G.


It has recently emerged that glutathione transferase enzymes (GSTs) and other structurally related molecules can be translocated from the external medium into many different cell types. In this study we aim to explore in detail, the structural features that govern cell translocation and by dissecting the human GST enzyme GSTM2-2 we quantatively demonstrate that the α-helical C-terminal domain (GST-C) is responsible for this property. Attempts to further examine the constituent helices within...[Show more]

CollectionsANU Research Publications
Date published: 2011-03-24
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0017864


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