Skip navigation
Skip navigation

Evolution from XIST-Independent to XIST-Controlled X-Chromosome Inactivation: Epigenetic Modifications in Distantly Related Mammals

Chaumeil, Julie; Waters, Paul D.; Koina, Edda; Gilbert, Clément; Robinson, Terence J.; Marshall Graves, Jennifer A.


X chromosome inactivation (XCI) is the transcriptional silencing of one X in female mammals, balancing expression of X genes between females (XX) and males (XY). In placental mammals non-coding XIST RNA triggers silencing of one X (Xi) and recruits a characteristic suite of epigenetic modifications, including the histone mark H3K27me3. In marsupials, where XIST is missing, H3K27me3 association seems to have different degrees of stability, depending on cell-types and species. However, the...[Show more]

CollectionsANU Research Publications
Date published: 2011-04-25
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0019040


File Description SizeFormat Image
01_Chaumeil_Evolution_from_2011.pdfPublished Version2.92 MBAdobe PDFThumbnail

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator