Evolution from XIST-Independent to XIST-Controlled X-Chromosome Inactivation: Epigenetic Modifications in Distantly Related Mammals
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Chaumeil, Julie; Waters, Paul D.; Koina, Edda; Gilbert, Clément; Robinson, Terence J.; Marshall Graves, Jennifer A.
Description
X chromosome inactivation (XCI) is the transcriptional silencing of one X in female mammals, balancing expression of X genes between females (XX) and males (XY). In placental mammals non-coding XIST RNA triggers silencing of one X (Xi) and recruits a characteristic suite of epigenetic modifications, including the histone mark H3K27me3. In marsupials, where XIST is missing, H3K27me3 association seems to have different degrees of stability, depending on cell-types and species. However, the...[Show more]
Collections | ANU Research Publications |
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Date published: | 2011-04-25 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/16899 |
Source: | PLoS ONE |
DOI: | 10.1371/journal.pone.0019040 |
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01_Chaumeil_Evolution_from_2011.pdf | Published Version | 2.92 MB | Adobe PDF | ![]() |
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