Effects of Heparin and Enoxaparin on APP Processing and Aβ Production in Primary Cortical Neurons from Tg2576 Mice
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Cui, Hao; Hung, Amos C.; Klaver, David W.; Suzuki, Toshiharu; Freeman, Craig; Narkowicz, Christian; Jacobson, Glenn A.; Small, David H.
Description
BACKGROUND Alzheimer's disease (AD) is caused by accumulation of Aβ, which is produced through sequential cleavage of β-amyloid precursor protein (APP) by the β-site APP cleaving enzyme (BACE1) and γ-secretase. Enoxaparin, a low molecular weight form of the glycosaminoglycan (GAG) heparin, has been reported to lower Aβ plaque deposition and improve cognitive function in AD transgenic mice. METHODOLOGY/PRINCIPAL FINDINGS We examined whether heparin and enoxaparin influence APP processing and...[Show more]
Collections | ANU Research Publications |
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Date published: | 2011-07-29 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/16890 |
Source: | PLoS ONE |
DOI: | 10.1371/journal.pone.0023007 |
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01_Cui_Effects_of_Heparin_and_2011.pdf | Published Version | 548.83 kB | Adobe PDF |
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