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Effects of Heparin and Enoxaparin on APP Processing and Aβ Production in Primary Cortical Neurons from Tg2576 Mice

Cui, Hao; Hung, Amos C.; Klaver, David W.; Suzuki, Toshiharu; Freeman, Craig; Narkowicz, Christian; Jacobson, Glenn A.; Small, David H.


BACKGROUND Alzheimer's disease (AD) is caused by accumulation of Aβ, which is produced through sequential cleavage of β-amyloid precursor protein (APP) by the β-site APP cleaving enzyme (BACE1) and γ-secretase. Enoxaparin, a low molecular weight form of the glycosaminoglycan (GAG) heparin, has been reported to lower Aβ plaque deposition and improve cognitive function in AD transgenic mice. METHODOLOGY/PRINCIPAL FINDINGS We examined whether heparin and enoxaparin influence APP processing and...[Show more]

CollectionsANU Research Publications
Date published: 2011-07-29
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0023007


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