Biswas, Sunita; Reinhard, Judith; Oakeshott, John Graham; Russell, Robyn; Srinivasan, Mandyam V; Claudianos, Charles
BACKGROUND Neurexins and neuroligins, which have recently been associated with neurological disorders such as autism in humans, are highly conserved adhesive proteins found on synaptic membranes of neurons. These binding partners produce a trans-synaptic bridge that facilitates maturation and specification of synapses. It is believed that there exists an optimal spatio-temporal code of neurexin and neuroligin interactions that guide synapse formation in the postnatal developing brain....[Show more]
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