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Directional Migration of Recirculating Lymphocytes through Lymph Nodes via Random Walks

Thomas, Niclas; Matejovicova, Lenka; Srikusalanukul, Wichat; Shawe-Taylor, John; Chain, Benny

Description

Naive T lymphocytes exhibit extensive antigen-independent recirculation between blood and lymph nodes, where they may encounter dendritic cells carrying cognate antigen. We examine how long different T cells may spend in an individual lymph node by examining data from long term cannulation of blood and efferent lymphatics of a single lymph node in the sheep. We determine empirically the distribution of transit times of migrating T cells by applying the Least Absolute Shrinkage & Selection...[Show more]

CollectionsANU Research Publications
Date published: 2012-09-20
Type: Journal article
URI: http://hdl.handle.net/1885/16865
Source: PLoS ONE
DOI: 10.1371/journal.pone.0045262

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