Evolutionary History and Attenuation of Myxoma Virus on Two Continents
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Kerr, Peter J.; Ghedin, Elodie; DePasse, Jay V.; Fitch, Adam; Cattadori, Isabella M.; Hudson, Peter J.; Tscharke, David C.; Read, Andrew F.; Holmes, Edward C.
Description
The attenuation of myxoma virus (MYXV) following its introduction as a biological control into the European rabbit populations of Australia and Europe is the canonical study of the evolution of virulence. However, the evolutionary genetics of this profound change in host-pathogen relationship is unknown. We describe the genome-scale evolution of MYXV covering a range of virulence grades sampled over 49 years from the parallel Australian and European epidemics, including the high-virulence...[Show more]
Collections | ANU Research Publications |
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Date published: | 2012-10-04 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/16863 |
Source: | PLoS Pathogens |
DOI: | 10.1371/journal.ppat.1002950 |
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01_Kerr_Evolutionary_History_and_2012.pdf | Published Version | 510.73 kB | Adobe PDF |
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