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Evolutionary History and Attenuation of Myxoma Virus on Two Continents

Kerr, Peter J.; Ghedin, Elodie; DePasse, Jay V.; Fitch, Adam; Cattadori, Isabella M.; Hudson, Peter J.; Tscharke, David C.; Read, Andrew F.; Holmes, Edward C.


The attenuation of myxoma virus (MYXV) following its introduction as a biological control into the European rabbit populations of Australia and Europe is the canonical study of the evolution of virulence. However, the evolutionary genetics of this profound change in host-pathogen relationship is unknown. We describe the genome-scale evolution of MYXV covering a range of virulence grades sampled over 49 years from the parallel Australian and European epidemics, including the high-virulence...[Show more]

CollectionsANU Research Publications
Date published: 2012-10-04
Type: Journal article
Source: PLoS Pathogens
DOI: 10.1371/journal.ppat.1002950


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