Serological Response in RT-PCR Confirmed H1N1-2009 Influenza A by Hemagglutination Inhibition and Virus Neutralization Assays: An Observational Study
Chen, Mark I.; Barr, Ian G.; Koh, Gerald C. H.; Lee, Vernon J.; Lee, Caroline P. S.; Shaw, Robert; Lin, Cui; Yap, Jonathan; Cook, Alex R.; Tan, Boon Huan; Loh, Jin Phang; Barkham, Timothy; Chow, Vincent T. K.; Lin, Raymond T. P.; Leo, Yee-Sin
BACKGROUND We describe the serological response following H1N1-2009 influenza A infections confirmed by reverse-transcriptase polymerase chain reaction (RT-PCR). METHODOLOGY AND PRINCIPAL FINDINGS The study included patients admitted to hospital, subjects of a seroepidemiologic cohort study, and participants identified from outbreak studies in Singapore. Baseline (first available blood sample) and follow-up blood samples were analyzed for antibody titers to H1N1-2009 and recently circulating...[Show more]
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