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High Resolution Melt Analysis (HRMA); a Viable Alternative to Agarose Gel Electrophoresis for Mouse Genotyping

Thomsen, Nicole; Ali, Radiya G.; Ahmed, Jehangir N.; Arkell, Ruth


Most mouse genetics laboratories maintain mouse strains that require genotyping in order to identify the genetically modified animals. The plethora of mutagenesis strategies and publicly available mouse alleles means that any one laboratory may maintain alleles with random or targeted insertions of orthologous or unrelated sequences as well as random or targeted deletions and point mutants. Many experiments require that different strains be cross bred conferring the need to genotype progeny at...[Show more]

CollectionsANU Research Publications
Date published: 2012-09-19
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0045252


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