Reduced Retinal Microvascular Density, Improved Forepaw Reach, Comparative Microarray and Gene Set Enrichment Analysis with c-jun Targeting DNA Enzyme
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Chan, Cecilia W. S; Kaplan, Warren; Parish, Christopher; Khachigian, Levon M
Description
Retinal neovascularization is a critical component in the pathogenesis of common ocular disorders that cause blindness, and treatment options are limited. We evaluated the therapeutic effect of a DNA enzyme targeting c-jun mRNA in mice with pre-existing retinal neovascularization. A single injection of Dz13 in a lipid formulation containing N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl-sulfate and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine inhibited c-Jun expression and...[Show more]
Collections | ANU Research Publications |
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Date published: | 2012-07-17 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/16845 |
Source: | PLoS ONE |
DOI: | 10.1371/journal.pone.0039160 |
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01_Chan_Reduced_Retinal_Microvascular_2012.pdf | Published Version | 3.8 MB | Adobe PDF | ![]() |
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