Skip navigation
Skip navigation

Reduced Retinal Microvascular Density, Improved Forepaw Reach, Comparative Microarray and Gene Set Enrichment Analysis with c-jun Targeting DNA Enzyme

Chan, Cecilia W. S; Kaplan, Warren; Parish, Christopher; Khachigian, Levon M

Description

Retinal neovascularization is a critical component in the pathogenesis of common ocular disorders that cause blindness, and treatment options are limited. We evaluated the therapeutic effect of a DNA enzyme targeting c-jun mRNA in mice with pre-existing retinal neovascularization. A single injection of Dz13 in a lipid formulation containing N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl-sulfate and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine inhibited c-Jun expression and...[Show more]

CollectionsANU Research Publications
Date published: 2012-07-17
Type: Journal article
URI: http://hdl.handle.net/1885/16845
Source: PLoS ONE
DOI: 10.1371/journal.pone.0039160

Download

File Description SizeFormat Image
01_Chan_Reduced_Retinal_Microvascular_2012.pdfPublished Version3.8 MBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  20 July 2017/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator