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Changes in the Expression of miR-381 and miR-495 Are Inversely Associated with the Expression of the MDR1 Gene and Development of Multi-Drug Resistance

Xu, Yan; Ohms, Stephen J; Li, Zhen; Wang, Qiao; Gong, Guangming; Hu, Yiqiao; Mao, Zhiyong; Shannon, M. Frances; Fan, Jun Y.


Multidrug resistance (MDR) frequently develops in cancer patients exposed to chemotherapeutic agents and is usually brought about by over-expression of P-glycoprotein (P-gp) which acts as a drug efflux pump to reduce the intracellular concentration of the drug(s). Thus, inhibiting P-gp expression might assist in overcoming MDR in cancer chemotherapy. MiRNAome profiling using next-generation sequencing identified differentially expressed microRNAs (miRs) between parental K562 cells and MDR K562...[Show more]

CollectionsANU Research Publications
Date published: 2013-11-26
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0082062


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