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Establishment of an In Vitro System Representing the Chicken Gut-Associated Lymphoid Tissue

Alitheen, Noorjahan Banu; McClure, Susan Jane; Yeap, Swee Keong; Kristeen-Teo, Ye Wen; Tan, Sheau Wei; McCullagh, Peter


The bursa of Fabricius is critical for B cell development and differentiation in chick embryos. This study describes the production in vitro, from dissociated cell suspensions, of cellular agglomerates with functional similarities to the chicken bursa. Co-cultivation of epithelial and lymphoid cells obtained from embryos at the appropriate developmental stage regularly led to agglomerate formation within 48 hours. These agglomerates resembled bursal tissue in having lymphoid clusters overlaid...[Show more]

CollectionsANU Research Publications
Date published: 2012-11-19
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0049188


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