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Maternally Administered Sustained-Release Naltrexone in Rats Affects Offspring Neurochemistry and Behaviour in Adulthood

Farid, Waleed O.; Lawrence, Andrew J.; Krstew, Elena V.; Tait, Robert J.; Hulse, Gary K.; Dunlop, Sarah A.


Naltrexone is not recommended during pregnancy. However, sustained-release naltrexone implant use in humans has resulted in cases of inadvertent foetal exposure. Here, we used clinically relevant dosing to examine the effects of maternally administered sustained-release naltrexone on the rat brain by examining offspring at birth and in adulthood. Maternal treatment (naltrexone or placebo implant) started before conception and ceased during gestation, birth or weaning. Morphometry was assessed...[Show more]

CollectionsANU Research Publications
Date published: 2012-12-26
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0052812


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