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The N-Terminal Intrinsically Disordered Domain of Mgm101p Is Localized to the Mitochondrial Nucleoid

Hayward, David C.; Dosztányi, Zsuzsanna; Clark-Walker, George Desmond


The mitochondrial genome maintenance gene, MGM101, is essential for yeasts that depend on mitochondrial DNA replication. Previously, in Saccharomyces cerevisiae, it has been found that the carboxy-terminal two-thirds of Mgm101p has a functional core. Furthermore, there is a high level of amino acid sequence conservation in this region from widely diverse species. By contrast, the amino-terminal region, that is also essential for function, does not have recognizable conservation. Using a...[Show more]

CollectionsANU Research Publications
Date published: 2013-02-13
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0056465


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