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Loss of pH Control in Plasmodium falciparum Parasites Subjected to Oxidative Stress

van Schalkwyk, Donelly A.; Saliba, Kevin J.; Biagini, Giancarlo A.; Bray, Patrick G.; Kirk, Kiaran

Description

The intraerythrocytic malaria parasite is susceptible to oxidative stress and this may play a role in the mechanism of action of some antimalarial agents. Here we show that exposure of the intraerythrocytic malaria parasite to the oxidising agent hydrogen peroxide results in a fall in the intracellular ATP level and inhibition of the parasite's V-type H(+)-ATPase, causing a loss of pH control in both the parasite cytosol and the internal digestive vacuole. In contrast to the V-type H(+)-ATPase,...[Show more]

CollectionsANU Research Publications
Date published: 2013-03-11
Type: Journal article
URI: http://hdl.handle.net/1885/16818
Source: PLoS ONE
DOI: 10.1371/journal.pone.0058933

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