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Reduced Interleukin-4 Receptor α Expression on CD8+ T Cells Correlates with Higher Quality Anti-Viral Immunity

Wijesundara, Danushka K.; Tscharke, David C.; Jackson, Ronald J.; Ranasinghe, Charani


With the hope of understanding how interleukin (IL)-4 and IL-13 modulated quality of anti-viral CD8(+) T cells, we evaluated the expression of receptors for these cytokines following a range of viral infections (e.g. pox viruses and influenza virus). Results clearly indicated that unlike other IL-4/IL-13 receptor subunits, IL-4 receptor α (IL-4Rα) was significantly down-regulated on anti-viral CD8(+) T cells in a cognate antigen dependent manner. The infection of gene knockout mice and...[Show more]

CollectionsANU Research Publications
Date published: 2013-01-31
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0055788


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