RBM5 Is a Male Germ Cell Splicing Factor and Is Required for Spermatid Differentiation and Male Fertility
O'Bryan, Moira K; Clark, Brett J; McLaughlin, Eileen A; D'Sylva, Rebecca J; O'Donnell, Liza; Wilce, Jacqueline A; Sutherland, Jessie; O'Connor, Anne E; Whittle, Belinda; Goodnow, Christopher C; Ormandy, Christopher J; Jamsai, Duangporn
Alternative splicing of precursor messenger RNA (pre-mRNA) is common in mammalian cells and enables the production of multiple gene products from a single gene, thus increasing transcriptome and proteome diversity. Disturbance of splicing regulation is associated with many human diseases; however, key splicing factors that control tissue-specific alternative splicing remain largely undefined. In an unbiased genetic screen for essential male fertility genes in the mouse, we identified the RNA...[Show more]
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