RBM5 Is a Male Germ Cell Splicing Factor and Is Required for Spermatid Differentiation and Male Fertility
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O'Bryan, Moira K; Clark, Brett J; McLaughlin, Eileen A; D'Sylva, Rebecca J; O'Donnell, Liza; Wilce, Jacqueline A; Sutherland, Jessie; O'Connor, Anne E; Whittle, Belinda; Goodnow, Christopher C; Ormandy, Christopher J; Jamsai, Duangporn
Description
Alternative splicing of precursor messenger RNA (pre-mRNA) is common in mammalian cells and enables the production of multiple gene products from a single gene, thus increasing transcriptome and proteome diversity. Disturbance of splicing regulation is associated with many human diseases; however, key splicing factors that control tissue-specific alternative splicing remain largely undefined. In an unbiased genetic screen for essential male fertility genes in the mouse, we identified the RNA...[Show more]
Collections | ANU Research Publications |
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Date published: | 2013-07-25 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/16794 |
Source: | PLoS Genetics |
DOI: | 10.1371/journal.pgen.1003628 |
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01_O'Bryan_RBM5_Is_a_Male_Germ_Cell_2013.pdf | Published Version | 8.05 MB | Adobe PDF | ![]() |
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