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Neuroinflammation and Neuronal Loss Precede Aβ Plaque Deposition in the hAPP-J20 Mouse Model of Alzheimer’s Disease

Wright, Amanda L.; Zinn, Raphael; Hohensinn, Barbara; Konen, Lyndsey M.; Beynon, Sarah B.; Tan, Richard P.; Clark, Ian A.; Abdipranoto, Andrea; Vissel, Bryce


Recent human trials of treatments for Alzheimer's disease (AD) have been largely unsuccessful, raising the idea that treatment may need to be started earlier in the disease, well before cognitive symptoms appear. An early marker of AD pathology is therefore needed and it is debated as to whether amyloid-βAβ? plaque load may serve this purpose. We investigated this in the hAPP-J20 AD mouse model by studying disease pathology at 6, 12, 24 and 36 weeks. Using robust stereological methods, we found...[Show more]

CollectionsANU Research Publications
Date published: 2013-04-01
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0059586


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