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A Missense Mutation in the Transcription Factor ETV5 Leads to Sterility, Increased Embryonic and Perinatal Death, Postnatal Growth Restriction, Renal Asymmetry and Polydactyly in the Mouse

Jamsai, Duangporn; Clark, Brett J.; Smith, Stephanie J.; Whittle, Belinda; Goodnow, Christopher C.; Ormandy, Christopher J.; O'Bryan, Moira K


ETV5 (Ets variant gene 5) is a transcription factor that is required for fertility. In this study, we demonstrate that ETV5 plays additional roles in embryonic and postnatal developmental processes in the mouse. Through a genome-wide mouse mutagenesis approach, we generated a sterile mouse line that carried a nonsense mutation in exon 12 of the Etv5 gene. The mutation led to the conversion of lysine at position 412 into a premature termination codon (PTC) within the ETS DNA binding domain of...[Show more]

CollectionsANU Research Publications
Date published: 2013-10-21
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0077311


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