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c-Rel Controls Multiple Discrete Steps in the Thymic Development of Foxp3+ CD4 Regulatory T Cells

Grigoriadis, George; Vasanthakumar, Ajithkumar; Banerjee, Ashish; Grumont, Raelene; Overall, Sarah; Gleeson, Paul; Shannon, Frances; Gerondakis, Steve


The development of natural Foxp3(+) CD4 regulatory T cells (nTregs) proceeds via two steps that involve the initial antigen dependent generation of CD25(+)GITR(hi)Foxp3(-)CD4(+) nTreg precursors followed by the cytokine induction of Foxp3. Using mutant mouse models that lack c-Rel, the critical NF-κB transcription factor required for nTreg differentiation, we establish that c-Rel regulates both of these developmental steps. c-Rel controls the generation of nTreg precursors via a...[Show more]

CollectionsANU Research Publications
Date published: 2011-10-31
Type: Journal article
Source: PLoS ONE
DOI: 10.1371/journal.pone.0026851


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