An Entropic Mechanism of Generating Selective Ion Binding in Macromolecules
Several mechanisms have been proposed to explain how ion channels and transporters distinguish between similar ions, a process crucial for maintaining proper cell function. Of these, three can be broadly classed as mechanisms involving specific positional constraints on the ion coordinating ligands which arise through: a "rigid cavity", a 'strained cavity' and 'reduced ligand fluctuations'. Each operates in subtly different ways yet can produce markedly different influences on ion selectivity....[Show more]
|Collections||ANU Research Publications|
|Source:||PLoS Computational Biology|
|01_Thomas_An_Entropic_Mechanism_of_2013.pdf||Published Version||1.35 MB||Adobe PDF|
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