An Entropic Mechanism of Generating Selective Ion Binding in Macromolecules
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Thomas, Michael; Jayatilaka, Dylan; Corry, Ben
Description
Several mechanisms have been proposed to explain how ion channels and transporters distinguish between similar ions, a process crucial for maintaining proper cell function. Of these, three can be broadly classed as mechanisms involving specific positional constraints on the ion coordinating ligands which arise through: a "rigid cavity", a 'strained cavity' and 'reduced ligand fluctuations'. Each operates in subtly different ways yet can produce markedly different influences on ion selectivity....[Show more]
Collections | ANU Research Publications |
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Date published: | 2013-02-28 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/16725 |
Source: | PLoS Computational Biology |
DOI: | 10.1371/journal.pcbi.1002914 |
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01_Thomas_An_Entropic_Mechanism_of_2013.pdf | Published Version | 1.35 MB | Adobe PDF |
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