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An Entropic Mechanism of Generating Selective Ion Binding in Macromolecules

Thomas, Michael; Jayatilaka, Dylan; Corry, Ben


Several mechanisms have been proposed to explain how ion channels and transporters distinguish between similar ions, a process crucial for maintaining proper cell function. Of these, three can be broadly classed as mechanisms involving specific positional constraints on the ion coordinating ligands which arise through: a "rigid cavity", a 'strained cavity' and 'reduced ligand fluctuations'. Each operates in subtly different ways yet can produce markedly different influences on ion selectivity....[Show more]

CollectionsANU Research Publications
Date published: 2013-02-28
Type: Journal article
Source: PLoS Computational Biology
DOI: 10.1371/journal.pcbi.1002914


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