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High Passage MIN6 Cells Have Impaired Insulin Secretion with Impaired Glucose and Lipid Oxidation

Cheng, Kim; Delghingaro-Augusto, Viviane; Nolan, Christopher J.; Turner, Nigel; Hallahan, Nicole; Andrikopoulos, Sofianos; Gunton, Jenny E.

Description

Type 2 diabetes is a metabolic disorder characterized by the inability of beta-cells to secrete enough insulin to maintain glucose homeostasis. MIN6 cells secrete insulin in response to glucose and other secretagogues, but high passage (HP) MIN6 cells lose their ability to secrete insulin in response to glucose. We hypothesized that metabolism of glucose and lipids were defective in HP MIN6 cells causing impaired glucose stimulated insulin secretion (GSIS). HP MIN6 cells had no first phase and...[Show more]

CollectionsANU Research Publications
Date published: 2012-07-13
Type: Journal article
URI: http://hdl.handle.net/1885/16719
Source: PLoS ONE
DOI: 10.1371/journal.pone.0040868

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