Spatial distribution of cerebral white matter lesions predicts progression to mild cognitive impairment and dementia
Mortamais, Marion; Reynes, Christelle; Brickman, Adam M.; Provenzano, Frank A.; Muraskin, Jordan; Portet, Florence; Berr, Claudine; Touchon, Jacques; Bonafé, Alain; le Bars, Emmanuelle; Maller, Jerome J.; Meslin, Chantal; Sabatier, Robert; Ritchie, Karen; Artero, Sylvaine
CONTEXT White matter lesions (WML) increase the risk of dementia. The relevance of WML location is less clear. We sought to determine whether a particular WML profile, based on the density and location of lesions, could be associated with an increased risk of mild cognitive impairment (MCI) or dementia over the following 7 years. METHODS In 426 healthy subjects from a cohort of community-dwelling people aged 65 years and over (ESPRIT Project), standardized cognitive and neurological evaluations...[Show more]
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